The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts
Identifieur interne : 006018 ( Main/Exploration ); précédent : 006017; suivant : 006019The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts
Auteurs : Mandy J. Ludford-Menting [Australie] ; Blessing Crimeen-Irwin [Australie] ; Jane Oliaro ; Anupama Pasam ; David Williamson ; Natalie Pedersen [Australie] ; Patricia Guillaumot [France] ; Dale Christansen [Australie] ; Serge Manie [France] ; Katharina Gaus ; Sarah M. RussellSource :
- Journal of Lipids [ 2090-3030 ] ; 2011.
Abstract
Many infectious agents utilize CD46 for infection of human cells, and therapeutic applications of CD46-binding viruses are now being explored. Besides mediating internalization to enable infection, binding to CD46 can directly alter immune function. In particular, ligation of CD46 by antibodies or by measles virus can prevent activation of T cells by altering T-cell polarity and consequently preventing the formation of an immunological synapse. Here, we define a mechanism by which CD46 reorients T-cell polarity to prevent T-cell receptor signaling in response to antigen presentation. We show that CD46 associates with lipid rafts upon ligation, and that this reduces recruitment of both lipid rafts and the microtubule organizing centre to the site of receptor cross-linking. These data combined indicate that polarization of T cells towards the site of CD46 ligation prevents formation of an immunological synapse, and this is associated with the ability of CD46 to recruit lipid rafts away from the site of TCR ligation.
Url:
DOI: 10.1155/2011/521863
PubMed: 21490803
PubMed Central: 3067059
Affiliations:
- Australie, France
- Auvergne-Rhône-Alpes, Rhône-Alpes, Victoria (État)
- Lyon, Melbourne
- Université Claude Bernard Lyon 1, Université de Melbourne
Links toward previous steps (curation, corpus...)
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- to stream Ncbi, to step Merge: 000A36
- to stream Ncbi, to step Curation: 000A36
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Le document en format XML
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Russell</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Lipids</title><idno type="ISSN">2090-3030</idno><idno type="eISSN">2090-3049</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Many infectious agents utilize CD46 for infection of human cells, and therapeutic applications of CD46-binding viruses are now being explored. Besides mediating internalization to enable infection, binding to CD46 can directly alter immune function. In particular, ligation of CD46 by antibodies or by measles virus can prevent activation of T cells by altering T-cell polarity and consequently preventing the formation of an immunological synapse. Here, we define a mechanism by which CD46 reorients T-cell polarity to prevent T-cell receptor signaling in response to antigen presentation. We show that CD46 associates with lipid rafts upon ligation, and that this reduces recruitment of both lipid rafts and the microtubule organizing centre to the site of receptor cross-linking. These data combined indicate that polarization of T cells towards the site of CD46 ligation prevents formation of an immunological synapse, and this is associated with the ability of CD46 to recruit lipid rafts away from the site of TCR ligation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Russell, S" uniqKey="Russell S">S Russell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riley Vargas, Rc" uniqKey="Riley Vargas R">RC Riley-Vargas</name></author><author><name sortKey="Gill, Db" uniqKey="Gill D">DB Gill</name></author><author><name sortKey="Kemper, C" uniqKey="Kemper C">C Kemper</name></author><author><name sortKey="Liszewski, Mk" uniqKey="Liszewski M">MK Liszewski</name></author><author><name sortKey="Atkinson, Jp" uniqKey="Atkinson J">JP Atkinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cattaneo, R" uniqKey="Cattaneo R">R 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sortKey="Schroeder, S" uniqKey="Schroeder S">S Schroeder</name></author><author><name sortKey="Sakakibara, Y" uniqKey="Sakakibara Y">Y Sakakibara</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tavano, R" uniqKey="Tavano R">R Tavano</name></author><author><name sortKey="Contento, Rl" uniqKey="Contento R">RL Contento</name></author><author><name sortKey="Baranda, Sj" uniqKey="Baranda S">SJ Baranda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Russell, S" uniqKey="Russell S">S Russell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krummel, Mf" uniqKey="Krummel M">MF Krummel</name></author><author><name sortKey="Macara, I" uniqKey="Macara I">I Macara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Humbert, Po" uniqKey="Humbert P">PO Humbert</name></author><author><name sortKey="Dow, Le" uniqKey="Dow L">LE Dow</name></author><author><name sortKey="Russell, Sm" uniqKey="Russell S">SM Russell</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li><li>Victoria (État)</li></region><settlement><li>Lyon</li><li>Melbourne</li></settlement><orgName><li>Université Claude Bernard Lyon 1</li><li>Université de Melbourne</li></orgName></list><tree><noCountry><name sortKey="Gaus, Katharina" sort="Gaus, Katharina" uniqKey="Gaus K" first="Katharina" last="Gaus">Katharina Gaus</name><name sortKey="Oliaro, Jane" sort="Oliaro, Jane" uniqKey="Oliaro J" first="Jane" last="Oliaro">Jane Oliaro</name><name sortKey="Pasam, Anupama" sort="Pasam, Anupama" uniqKey="Pasam A" first="Anupama" last="Pasam">Anupama Pasam</name><name sortKey="Russell, Sarah M" sort="Russell, Sarah M" uniqKey="Russell S" first="Sarah M." last="Russell">Sarah M. Russell</name><name sortKey="Williamson, David" sort="Williamson, David" uniqKey="Williamson D" first="David" last="Williamson">David Williamson</name></noCountry><country name="Australie"><noRegion><name sortKey="Ludford Menting, Mandy J" sort="Ludford Menting, Mandy J" uniqKey="Ludford Menting M" first="Mandy J." last="Ludford-Menting">Mandy J. Ludford-Menting</name></noRegion><name sortKey="Christansen, Dale" sort="Christansen, Dale" uniqKey="Christansen D" first="Dale" last="Christansen">Dale Christansen</name><name sortKey="Crimeen Irwin, Blessing" sort="Crimeen Irwin, Blessing" uniqKey="Crimeen Irwin B" first="Blessing" last="Crimeen-Irwin">Blessing Crimeen-Irwin</name><name sortKey="Pedersen, Natalie" sort="Pedersen, Natalie" uniqKey="Pedersen N" first="Natalie" last="Pedersen">Natalie Pedersen</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Guillaumot, Patricia" sort="Guillaumot, Patricia" uniqKey="Guillaumot P" first="Patricia" last="Guillaumot">Patricia Guillaumot</name></region><name sortKey="Manie, Serge" sort="Manie, Serge" uniqKey="Manie S" first="Serge" last="Manie">Serge Manie</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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